Greek rule did not survive in northwestern India, although a school of art known as Indo-Greek developed and influenced art as far as Central Asia. The region of Gandhara was conquered by Chandragupta (r. ca. 321-ca. 297 B.C.), the founder of the Mauryan Empire, the first universal state of northern India, with its capital at present-day Patna in Bihar. His grandson, Ashoka (r. ca. 274-ca. 236 B.C.), became a Buddhist. Taxila became a leading center of Buddhist learning. Successors to Alexander at times controlled the northwestern of region present-day Pakistan and even Punjab after Maurya power waned in the region.

The northern regions of Pakistan came under the rule of the Sakas, who originated in Central Asia in the second century B.C. They were soon driven eastward by Pahlavas (Parthians related to the Scythians), who in turn were displaced by the Kushans (also known as the Yueh-Chih in Chinese chronicles).

The Kushans had earlier moved into territory in the northern part of present-day Afghanistan and had taken control of Bactria. Kanishka, the greatest of the Kushan rulers (r. ca. A.D. 120-60), extended his empire from Patna in the east to Bukhara in the west and from the Pamirs in the north to central India, with the capital at Peshawar (then Purushapura) (see fig. 3). Kushan territories were eventually overrun by the Huns in the north and taken over by the Guptas in the east and the Sassanians of Persia in the west.

The age of the imperial Guptas in northern India (fourth to seventh centuries A.D.) is regarded as the classical age of Hindu civilization. Sanskrit literature was of a high standard; extensive knowledge in astronomy, mathematics, and medicine was gained; and artistic expression flowered. Society became more settled and more hierarchical, and rigid social codes emerged that separated castes and occupations. The Guptas maintained loose control over the upper Indus Valley.

Northern India suffered a sharp decline after the seventh century. As a result, Islam came to a disunited India through the same passes that Indo-Aryans, Alexander, Kushans, and others had entered.