Antioch was in Syria, on the eastern side of the Orontes River.
I Nicator, a general under Alexander the Great, founded Antioch, and made it the capital of his Seleucid Empire by 300 B.C. When Rome annexed the territory of Tigranes, king of Armenia, Antioch came under Roman dominion and became the capital of the province of Syria.
Antioch was an Apostolic See and one of the first four patriarchates; the others were Jerusalem, Alexandria, and Rome. Antioch is said to be the place where the name "Christian" was first applied. St. Peter was the first bishop of Antioch.
Antioch (Antakya) is now in Turkey. The Antiochan Church is no longer headquartered in Antioch, but in Damascus, still in Syria.
Alternate Spellings: Antakya